I3C and DIM
Indole-3-carbinol (I3C) and 3-3’-diindolylmethane (DIM) are natural metabolites of compounds found in numerous vegetables from the Brassicaceae family. Following I3C ingestion either through the diet or supplementation, I3C molecules combine to form a complex group of compounds in the acidic environment of the stomach, one of which is DIM.
Both I3C and DIM, as well as many other I3C metabolites, have been shown to impact metabolic shifts and cellular activities for improved health outcomes. Additionally, both I3C and DIM have been shown in vitro to decrease aromatase expression, which is the enzyme that converts androgens to estrogen. Further, I3C has been shown to temper estrogen signals by competing for binding sites and inhibiting the activity of estrogen receptors.
Calcium D-Glucarate
Calcium D-glucarate is the supplemental calcium salt form of D-glucaric acid, a substance produced naturally in the body and obtained through consumption of certain fruits and vegetables. Calcium D-glucarate has been extensively studied and has been shown to inhibit beta-glucuronidase, an enzyme found in certain bacteria that reside in the gut. This activity supports the body’s ability to detoxify estrogens, foreign molecules and fat-soluble toxins.
