Core B Complex supports essential body functions through methylation, a vitamin-dependent biochemical process crucial for mental and physical health. Methylation helps regulate gene expression, repair DNA continually, and maintain cellular health. It occurs billions of times each second, but when it slows, DNA damage increases. Beyond DNA repair, methylation is vital for producing neurotransmitters, balancing homocysteine for heart health, and recycling molecules needed for detoxification and managing inflammation. It also supports energy metabolism, immune response, and nerve cell function.

Nutrient deficiencies such as folate, B2, B6, and B12 can hinder proper methylation, and certain medications may further deplete these vital nutrients. Core B Complex delivers high-concentration folate as Quatrefolic®—the biologically active 5-MTHF form—along with trimethylglycine, and the essential methylation vitamins B2, B6, and B12 (methylcobalamin). This blend of methyl donors enhances DNA repair, maintains homocysteine levels, supports neurotransmitter production, balances hormones, and optimizes detoxification processes.


Equivalent to Methyl CPG. May be substituted without notice, containing the same ingredients under the Ortho Molecular label.

Take 1 capsule per day or as recommended by your health care professional.

Folate

Folate is a water soluble member of the B complex vitamins that is critical for maintaining optimal methylation. Folate is abundantly found in foods such as fruits and dark leafy vegetables but, can be easily destroyed by cooking or processing. The bioactive form of folate is 5-methyltetrahydrofolate (5-MTHF). 5-MTHF is required as a methyl group donor for several processes, including the production of mood regulating neurotransmitters, the synthesis of melatonin, and DNA production and repair.

Vitamin B12

Vitamin B12 works with folate in many body processes, including the synthesis of DNA, red blood cells and supporting health of the myelin sheath, the insulating exterior that surrounds nerve cells. B12 is found primarily in animal foods. Vegetarians and the elderly run the highest risk of B12 deficiency. Methylcobalamin is the preferred form of B12 as it is the biologically active form of B12 and supports the up-regulation of methylation pathways.

Vitamin B6

Vitamin B6 is a crucial B vitamin that is involved in the production of proteins in the body, neurotransmitters that help regulate mood, red blood cell formation and the proper functioning of the immune system. B6 is required for more than 60 different enzymatic reactions that occur in the body. Vitamin B6 works along with 5-MTHF and B12 in the recycling of homocysteine. B6 also supports a healthy cardiovascular system by promoting healthy platelet aggregation and aids in maintaining normal blood pressure.

Vitamin B2

Optimizing B2 (riboflavin) status helps support healthy blood pressure. Supporting riboflavin status also appears to stabilize MTHFR, the enzyme required for 5-MTHF which converts homocysteine to methionine.

Trimethylglycine (Betaine)

As a methyl donor, trimethylglycine supports liver function, including detoxification pathways. Trimethylglycine has been shown to protect against chemical damage to the liver. It has also been shown to be beneficial in protecting against fat accumulation in the liver, due to its lipotropic properties. Trimethylglycine also works alongside B2, B6, B12 and folate in maintaining normal homocysteine levels.

Riboflavin (Vitamin B2 USP), Vitamin B6 (as Pyridoxine Hydrochloride USP), Folate (from 2,000 mcg as Quatrefolic® (6S)-5-Methyltetrahydrofolic acid glucosamine salt), Vitamin B12 (as Methylcobalamin), Betaine (Trimethylglycine)