Estrogen plays a crucial role in the body, acting as a key hormone messenger particularly in tissues sensitive to it, such as those in the breast and prostate. It primarily instructs cells to grow, divide, and multiply, which is vital for human development and tissue repair. However, maintaining proper estrogen synthesis, metabolism, and detoxification is critical for optimal hormonal balance.

DIM CDG combines the powerful effects of two cruciferous vegetable metabolites, indole-3-carbinol (I3C) and 3-3’-diindolylmethane (DIM), to support balanced estrogen metabolism. This formulation leverages the synergistic properties of I3C and DIM to promote estrogen balance, enhancing health in both breast and prostate tissues. Crafted to support your body’s natural processes, DIM CDG is your go-to supplement for maintaining hormonal health and well-being.


Equivalent to CDG EstroDIM. May be substituted without notice, containing the same ingredients under the Ortho Molecular label.

Take 2 capsules per day or as recommended by your health care professional.

I3C and DIM

Indole-3-carbinol (I3C) and 3-3’-diindolylmethane (DIM) are natural metabolites of compounds found in numerous vegetables from the Brassicaceae family. Following I3C ingestion either through the diet or supplementation, I3C molecules combine to form a complex group of compounds in the acidic environment of the stomach, one of which is DIM.

Both I3C and DIM, as well as many other I3C metabolites, have been shown to impact metabolic shifts and cellular activities for improved health outcomes. Additionally, both I3C and DIM have been shown in vitro to decrease aromatase expression, which is the enzyme that converts androgens to estrogen. Further, I3C has been shown to temper estrogen signals by competing for binding sites and inhibiting the activity of estrogen receptors.

Calcium D-Glucarate

Calcium D-glucarate is the supplemental calcium salt form of D-glucaric acid, a substance produced naturally in the body and obtained through consumption of certain fruits and vegetables. Calcium D-glucarate has been extensively studied and has been shown to inhibit beta-glucuronidase, an enzyme found in certain bacteria that reside in the gut. This activity supports the body’s ability to detoxify estrogens, foreign molecules and fat-soluble toxins.

Vitamin E (from 50 IU as d-Alpha Tocopherol Succinate USP), Calcium (as Calcium D-Glucarate USP), Calcium D-Glucarate, Dietary Indoles (Total Indole Blend containing Indole-3-Carbinol (I3C, 200 mg input) and Diindolylmethane (DIM, 100 mg input))