Modern lifestyle habits such as poor diet, insufficient sleep, high stress, exposure to chemicals, and extreme physical activity can lead to physiological stress on our bodies. Although our bodies are equipped to manage stress, detoxify chemicals, and preserve cellular function, an overload can overwhelm these natural systems. A common result is the depletion of reduced glutathione, our body’s most potent antioxidant.

Often referred to as “the master antioxidant,” glutathione is crucial for neutralizing free radicals and protecting cells from damage. While it was once believed that humans could not effectively utilize preformed glutathione, recent research, including studies on Setria®, a unique tri-peptide form of glutathione, has shown otherwise. This form of glutathione is specifically structured to enhance blood levels when ingested and is the only supplement of its kind supported by a human clinical trial confirming significant absorption of this essential nutrient.


Equivalent to L-Glutathione. May be substituted without notice, containing the same ingredients under the Ortho Molecular label.

Take 1 capsule per day or as recommended by your healthcare professional.

L-Glutathione and Detoxification

Because of glutathione’s central role in detoxification, about 25% of all glutathione resides in the liver. Glutathione is more than simply an electron donor; glutathione plays an important role in protecting living cells from toxicity by detoxifying the reactive intermediates via enzymatic conjugation. Glutathione can also function as a detoxifying agent within the intestinal lumen, catching harmful toxins before they enter the body and create the necessity for liver detoxification.

L-Glutathione and Immune Health

It is well known that the gastrointestinal cells, the mitochondria and the efficiency of immune cell function are three major factors in immune function. Glutathione happens to play a role in all three elements. When small intestinal mucosa atrophies, it causes an increase in epithelial permeability and compromised tight junctions, which can lead to translocation of bacteria. This translocation of bacteria is implicated in immune activation and autoimmunity. Supplementing with oral glutathione under conditions in which intracellular glutathione status is compromised can restore tissue glutathione and promote ROS metabolism.

L-Glutathione (Reduced) (Setria®)