Hist-a-Core is a blend of flavonoids, antioxidants, proteolytic enzymes, and botanicals, designed to deliver substantial relief from seasonal discomfort caused by common environmental allergens. This formula features key components such as quercetin, bromelain, stinging nettles leaf, and N-acetyl cysteine, which work synergistically to mitigate the effects of elevated histamine levels and respiratory irritants.

The inclusion of quercetin helps stabilize mast cells, reducing the release of histamine, while bromelain assists in decreasing mucosal inflammation and improving nasal airflow. Stinging nettles leaf is recognized for its ability to provide broad support for inflammatory responses and allergy symptoms. N-acetyl cysteine acts as a potent antioxidant that helps thin mucus and enhance mucociliary clearance, promoting clear nasal and sinus passages. Hist-a-Core is formulated to enhance your body’s natural defenses, promoting healthy respiratory function during allergy season and beyond, making it an ideal choice for those seeking natural and effective allergy support.


Equivalent to Natural D-Hist. May be substituted without notice, containing the same ingredients under the Ortho Molecular label.

Initial Dosage: Take 2 capsules three times daily for 7-10 days, or follow your healthcare professional's advice.

Ongoing Use: Take 2 or more capsules daily, or as advised by your healthcare professional.

Quercetin

Quercetin is a biologically active flavonoid antioxidant that is widely distributed in plants, including oak trees, onions and tea. Quercetin has strong antioxidant activity and has been shown to support immune health by mediating the release of inflammatory compounds, including leukotrienes and prostaglandins. Quercetin is known for its ability to stabilize mast cells, which diminishes the release of histamine, the compound known to cause hypersensitivity reactions during seasonal changes.

Stinging Nettles Leaf

Urtica dioica, commonly known as stinging nettles, is a plant that has been shown to balance immune response, specifically in the airways and nasal passages. Stinging nettles leaf controls mast-cell degranulation, prostaglandin formation and histamine action, which all contribute to a balanced inflammatory response.

Bromelain

Bromelain is a plant enzyme naturally found on the stem and fruit of the pineapple plant. Bromelain is a proteolytic enzyme that aids in the breakdown of large protein complexes, including antigenic compounds, and has been shown to enhance the absorption of quercetin. Bromelain has been shown to reduce circulating allergenic protein complexes associated with hyperimmune sensitivity and seasonal discomfort.

N-Acetyl Cysteine

N-acetyl cysteine (NAC) is an amino acid precursor to one of the most important antioxidants in the body, glutathione. Both glutathione and NAC help reduce the mucus viscosity to maintain cleared airways and respiratory health.

Vitamin C

Humans cannot synthesize vitamin C, and it is, therefore, an essential nutrient that must be consumed in the diet. Among its numerous health-promoting properties, vitamin C is an essential vitamin that supports the immune system and is also a potent antioxidant. When the body is under a significant amount of emotional or environmental stress, vitamin C is excreted rapidly. Vitamin C has many immune-boosting properties but is distinctively beneficial for individuals with seasonal discomfort because of its ability to deactivate histamine.

Vitamin C (as Ascorbic Acid USP), Quercetin Dihydrate, Stinging Nettle (Leaves), Bromelain (from Pineapple), N-Acetyl-Cysteine USP