Hormones, particularly estrogen, play essential roles in human development and tissue repair, but their proliferative effects need to be carefully managed to maintain optimal health. Estrogen undergoes various metabolic processes, resulting in metabolites that can be either beneficial or potentially harmful. Therefore, supporting estrogen synthesis and detoxification is crucial for hormonal balance.

DIM Plus is a specialized supplement that harnesses the combined power of cruciferous vegetable metabolites, specifically indole-3-carbinol (I3C) and 3-3’-diindolylmethane (DIM). This synergy creates an optimal blend of metabolites that help regulate estrogen metabolism. By maintaining estrogen balance and supporting cellular health, DIM Plus is particularly beneficial for both breast and prostate health, making it an essential part of your wellness regimen.


Equivalent to EstroDIM. May be substituted without notice, containing the same ingredients under the Ortho Molecular label.

Take 1 capsule per day or as recommended by your health care professional.

I3C & DIM

Indole-3-carbinol (I3C) and diindolylmethane (DIM) are natural metabolites of compounds found in numerous vegetables from the Brassicaceae family. Both I3C and DIM, as well as many other I3C metabolites, have been shown to impact metabolic shifts and cellular activities for improved health outcomes. I3C and DIM have been shown to induce some phase I and phase II biotransformation genes in preclinical models through pathways such as Nrf2, suggesting I3C and DIM may have a role in detoxification. Additionally, both I3C and DIM have been shown in vitro to decrease aromatase expression, the enzyme that converts androgens to estrogen.

Vitamin E (from 50 IU as d-Alpha Tocopherol Succinate USP), Dietary Indoles (Total Indole Blend containing Indole-3-Carbinol (I3C, 200 mg input) and Diindolylmethane (DIM, 100 mg input))