Suggested Use: 2 packets per day, one AM packet in the morning and one PM packet in the evening or as recommended by your health care professional

Maintenance: 1 packet per day, alternating one AM packet on odd days and one PM packet on even days or as recommended by your health care professional.

• Strontium
Strontium is a mineral that is similar to the physical and chemical properties of calcium. Research has shown strontium to provide all natural bone support through its ability to increase the formation of osteoblasts while decreasing the formation of osteoclasts. Strontium also provides an anabolic effect on bone by stimulating bone morphogenic proteins and enhancing calcium deposition and mineralization in the bone matrix.

• Calcium
Nearly 99% of the calcium within the adult skeletal system exists as a complex paired with phosphorus, called hydroxyapatite. It is commonly advised that individuals past early adolescence consume 1,000 to 1,500 mg/ day from dietary or supplement sources to support bone formation. Pro Bono® is formulated with calcium citrate malate and calcium hydroxyapatite to improve absorption and support optimal bone health.

• Magnesium
Magnesium plays a major role in bone formation as approximately 50% of magnesium found in the body is found in the bone. Magnesium plays numerous roles in bone health, including increasing calcium absorption, acting as a cofactor for alkaline phosphatase activation and supporting vitamin D3 conversion in the body. Magnesium deficiency is very common; many Americans fail to acquire even the estimated average requirement (EAR). Magnesium deficiency can also be exacerbated due to factors such as excess consumption of alcohol, salt, coffee, phosphoric acid in sodas, and long-term stress.

• Vitamin D3 (Cholecalciferol)
Vitamin D is a steroid vitamin that is known for its role in supporting bone health and aiding in the absorption of calcium and phosphate from the GI tract.

• Vitamin K1 (Phytonedione) & Vitamin K2 (Menaquinone)
Vitamin K is responsible for synthesizing osteocalcin, a protein involved in calcium transport and properly embedding calcium into bone tissue. Vitamin K has also been shown to decrease the activity of osteoclasts, which helps to maintain bone formation and strength. Vitamin K works synergistically with vitamin D3 to improve calcium absorption and helps to bind newly absorbed calcium to the bone matrix.

• Boron
Boron supplementation reduced urinary excretion of calcium and magnesium and increased blood levels of 17 betaestradiol and testosterone in postmenopausal women in one study. Improving boron levels has been shown to support bone health.

Vitamin A (from 2,000 IU per AM and PM Packets, 4,000 IU per 2 Packets as Natural Beta Carotene, Palmitate), Vitamin C (as Ascorbic Acid USP), Vitamin D (D3 as Cholecalciferol), Vitamin E (from 25 IU per AM and PM Packets, 50 IU per 2 Packets as d-Alpha Tocopherol Succinate USP), Vitamin K (K1 as Phytonadione), Thiamin (Vitamin B1) (from Thiamine Hydrochloride USP), Riboflavin (Vitamin B2 USP), Niacin
(as Niacin USP, Niacinamide USP), Vitamin B6 (as Pyridoxine Hydrochloride USP), Folate (from 400 mcg per AM and PM Packets, 800 mcg per 2 Packets Quatrefolic® (6S)-5-Methyltetrahydrofolic acid glucosamine salt), Vitamin B12 (as Methylcobalamin), Biotin, Pantothenic Acid (as d-Calcium Pantothenate USP), Calcium (as Calcium Hydroxyapatite, Albion® Minerals Dicalcium Malate), Phosphorus
(as Calcium Hydroxyapatite), Iodine (from Potassium iodide), Magnesium (as DiMagnesium Malate, Magnesium Citrate USP, Albion® Minerals Magnesium Lysinate Glycinate Chelate), Zinc (as Albion® Minerals Zinc Bisglycinate Chelate), Selenium (as Selenium Glycinate Complex), Copper
(as Albion® Minerals Copper Bisglycinate Chelate), Manganese (as Albion® Minerals Manganese Bisglycinate Chelate, Chromium (as O-polynicotinate)‡, Molybdenum
(as Albion® Minerals Molybdenum Glycinate Chelate), Strontium Citrate, Boron (as Bororganic Glycine), Vitamin K2 (as Menaquinone-7 (MK-7)) (MenaQ7®PRO)