Effective radioprotective actions show that including melatonin as an adjuvant in radiation therapy may decrease the normal tissue damage induced by irradiation, which leads to more tumor control by use of higher doses of irradiation during radiotherapy.

Furthermore, due to its antitumor and radiosensitizing properties, treatment with melatonin is likely to increase damage to the tumor.

• Direct anti-neoplastic effects.
• Decreases cell proliferation at low concentrations.
• Direct cytotoxic effect occurs with high concentrations
• Stimulation of cell differentiation
• Induction of apoptosis
• Anti-angiogenesis
• A synergistic effect has been found in several cancer types when it is administered in combination with chemotherapy.
• Melatonin activates anti-neoplastic immune reactivity
• Direct anticancer action
• Protects against chemo radiation damage

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